Sample Sizes for Clinical Trials, 2nd Edition (EPUB)

Features:

• Comprehensive coverage of sample size calculations, including Normal, binary, ordinal, and survival outcome data
• Covers superiority, equivalence, non-inferiority, bioequivalence and precision objectives for both parallel group and crossover designs
• Highlights how trial objectives impact the study design with respect to both the derivation of sample formulae and the size of the study
• Motivated with examples of real-life clinical trials showing how the calculations can be applied
• New edition is extended with all chapters revised, some substantially, and four completely new chapters on multiplicity, cluster trials, pilot studies, and single arm trials

The book is primarily aimed at researchers and practitioners of clinical trials and biostatistics, and could be used to teach a course on sample size calculations. The importance of a sample size calculation when designing a clinical trial is highlighted in the book. It enables readers to quickly find an appropriate sample size formula, with an associated worked example, complemented by tables to assist in the calculations.